The mod­ern rhythm of life dic­tates its own rules. Stress, unfor­tu­nate­ly, has become almost a reg­u­lar com­pan­ion of human life. Not every­one can cope with this prob­lem sole­ly by the forces of their body.

You need to know that most seda­tive drugs “reach their max­i­mum” one to two weeks after the start of treat­ment. There­fore, there is no need to rush and exceed the dosage spec­i­fied in the instruc­tions, even if at first it seems that the med­i­cine “does not work”.

The best synthetic products



Soothes, reduces anx­i­ety, nor­mal­izes the neu­ropsy­chic state when try­ing to quit smok­ing or “tie up” with alco­hol, dur­ing PMS. Improves sleep if prob­lems with falling asleep are caused by unpleas­ant thoughts. Com­bined with alco­holic bev­er­ages, which allows you not to attract undue atten­tion to your­self at fam­i­ly and friend­ly hol­i­days. Not to be tak­en dur­ing preg­nan­cy, breast­feed­ing and under 18 years of age. Due to the fact that the tablets con­tain lac­tose as an aux­il­iary com­po­nent (filler), they can­not be used by peo­ple who are intol­er­ant to this sub­stance. In gen­er­al, this is an extreme­ly small list of con­traindi­ca­tions for a seda­tive, there­fore, for the com­bi­na­tion of effec­tive­ness and safe­ty, Afobazole takes its right­ful place in our rat­ing.



This com­po­si­tion has been used for many years, and our grand­moth­ers used it. Bro­moiso­va­ler­ic acid eth­yl ester, pep­per­mint and oregano oils dis­solved in alco­hol. Phe­no­bar­bi­tal, a well-known sleep­ing pill, is added at a dosage low­er than ther­a­peu­tic, but suf­fi­cient to poten­ti­ate the effect of herbal seda­tives. When used cor­rect­ly in dos­es not exceed­ing those spec­i­fied in the instruc­tions (from 15 to 30 drops no more than 3 times a day), the drug is not addic­tive. How­ev­er, phe­no­bar­bi­tal in its com­po­si­tion enhances the effect of not only plant extracts, but also any seda­tives and reduces the effect of ton­ics. In addi­tion, it reduces the effect of antibi­otics and con­tra­cep­tives. Con­traindi­cat­ed in preg­nan­cy, dur­ing feed­ing, up to 18 years. In gen­er­al, val­oserdin is inex­pen­sive, quite effec­tive, despite its ven­er­a­ble age, and a fair­ly safe rem­e­dy, which, due to the total­i­ty of mer­its, has received a place in our rat­ing.

Tryptophan Calm Formula

Tryp­to­phan Calm For­mu­la

The unique mech­a­nism of action of the amino acid, which gave the drug its name, allows it to ful­ly influ­ence the human body both dur­ing the day and at night, help­ing to nor­mal­ize the psy­cho-emo­tion­al back­ground and improve the qual­i­ty of sleep. For­ti­fied with vit­a­mins B5 and B6, L‑tryptophan helps to quick­ly cope with ner­vous­ness, reduces aggres­sive­ness and irri­tabil­i­ty, and also reduces the adap­ta­tion peri­od when chang­ing time zones. For best results, this rem­e­dy is rec­om­mend­ed to take 1 cap­sule twice a day for 1 month. If nec­es­sary, after a short break, the course can be repeat­ed (after agree­ment with the doc­tor).

In their reviews, many users note the good effect of the drug, but there are those who did not feel the expect­ed effect at all. Due to such mixed rat­ings, we leave Tryp­to­phan Calm For­mu­la in last place in its cat­e­go­ry of the best seda­tives.

The Best Herbal Products



It would seem that this rem­e­dy has a place among syn­thet­ic drugs due to the pres­ence of guaife­n­esin in it. Like diphen­hy­dramine, which was devel­oped as an anti-aller­gic and is now used main­ly as a sleep­ing pill and seda­tive, guaife­n­esin was patent­ed in 2012 as an anti­tus­sive drug and is now used as an anx­i­ety reliev­er. How­ev­er, the sub­stance is of nat­ur­al ori­gin and is extract­ed from the bark of the gua­iac tree, which allowed Novopas­sit to take its place in the rank­ing as the best herbal prepa­ra­tion with an anx­i­olyt­ic effect. Because its main com­po­nents are entire­ly nat­ur­al: rhi­zomes and roots of valer­ian, lemon balm, St. John’s wort, hawthorn, pas­sion flower, hops, elder­ber­ry. Of the con­traindi­ca­tions — age up to 12 years, aller­gy to the com­po­nents of the drug. A rel­a­tive con­traindi­ca­tion is preg­nan­cy.



The com­po­si­tion of this rem­e­dy is tra­di­tion­al and sim­ple: an extract of valer­ian, lemon balm and pep­per­mint. How­ev­er, this com­bi­na­tion appears to be very effec­tive as a sleep aid. But you need to use it dur­ing the day with cau­tion, espe­cial­ly if you dri­ve a car: side effects such as lethar­gy and lethar­gy are pos­si­ble, which are typ­i­cal, how­ev­er, for any valer­ian-based prod­uct. Nev­er­the­less, in adults, the choice of seda­tives that do not affect the reac­tion is quite large, but the fact that the drug can be used by chil­dren from the age of three is a def­i­nite plus of this med­i­cine, mak­ing it the best in its cat­e­go­ry.

Motherwort Forte Evalar

Moth­er­wort Forte Evalar

One of the most pop­u­lar and time-test­ed nat­ur­al seda­tive prepa­ra­tions based on moth­er­wort extract has not only a seda­tive, but also a ton­ic effect on the body. One tablet of “Moth­er­wort Forte” from the com­pa­ny Evalar con­tains a dai­ly dose of mag­ne­sium car­bon­ate and vit­a­min B6, which helps to quick­ly relieve feel­ings of emo­tion­al stress, removes anx­i­ety and irri­tabil­i­ty. In addi­tion, the drug helps to gen­tly reduce blood pres­sure, strength­ens the heart mus­cle and acts as a del­i­cate mus­cle relax­ant. The undoubt­ed “plus” of the rem­e­dy is that it is not addic­tive even with a long peri­od of ther­a­py.

The rec­om­mend­ed dosage (if the attend­ing physi­cian has not pre­scribed anoth­er appoint­ment) is 1–2 tablets. per day, tak­en with meals. Con­traindi­ca­tions include preg­nan­cy, pep­tic ulcer of the stom­ach and duo­de­num, as well as ero­sive gas­tri­tis in the acute stage. Sold with­out a pre­scrip­tion.

The best homeopathic remedies



Accord­ing to the instruc­tions, the drug has anti­de­pres­sant, anti­as­thenic (reduces fatigue) and anx­i­olyt­ic (anti-anx­i­ety) effects. Also, accord­ing to the man­u­fac­tur­er, the tool strength­ens the cen­tral ner­vous sys­tem, improves atten­tion and mem­o­ry and increas­es the body’s resis­tance to stress. Approved for use in chil­dren from 3 years of age.

Rescue Remedy Spray

Res­cue Rem­e­dy Spray

The action of the home­o­path­ic rem­e­dy pro­duced by the British phar­ma­ceu­ti­cal com­pa­ny A. Nel­son & Co. Lim­it­ed is based on Bach’s flower home­opa­thy — a direc­tion of non-tra­di­tion­al ther­a­py that helps the body with ner­vous strain. In Rus­sia, brand drugs have under­gone manda­to­ry reg­is­tra­tion by the Min­istry of Health, so their use is offi­cial­ly allowed.

Due to its non-stan­dard form of release, Res­cue Rem­e­dy sub­lin­gual spray has the fastest action, which is espe­cial­ly impor­tant for restor­ing the emo­tion­al back­ground in stress­ful sit­u­a­tions. Avail­able in bot­tles of 10 and 20 ml. The rec­om­mend­ed dai­ly dose is at least 4 sprays per day. The com­po­si­tion includes grape alco­hol, so the spray is con­traindi­cat­ed in chil­dren under 3 years old. There was no par­tic­u­lar effect of small dos­es of the drug on dri­vers or work­ers in oth­er areas requir­ing increased atten­tion. Accord­ing to user reviews, Res­cue Rem­e­dy is an effec­tive first aid that can save our ner­vous sys­tem in times of dif­fi­cult cir­cum­stances.



French lozenges “Home­ostres” based on bel­ladon­na herb and wrestler clobuche (also known to us as “wolf root”) are a mul­ti-com­po­nent home­o­path­ic prepa­ra­tion to com­bat anx­i­ety, irri­tabil­i­ty and insom­nia. The tool has a fair­ly strong effect on the ner­vous sys­tem, so it has a lim­it­ed peri­od of admis­sion — no more than one week. The max­i­mum dai­ly allowance is 6 tablets, which are rec­om­mend­ed to be slow­ly absorbed in the oral cav­i­ty, 2 pcs. three times a day.

It should be not­ed that the com­po­si­tion, in addi­tion to active sub­stances, includes lac­tose and sucrose. There­fore, peo­ple with ele­vat­ed blood sug­ar lev­els (dia­bet­ics of the 1st and 2nd type), as well as those who have been diag­nosed with hypo­lac­ta­sia, should use Home­ostres with extreme cau­tion. The drug is pre­scribed only for adult patients. It is con­traindi­cat­ed in chil­dren, preg­nant and lac­tat­ing women.

Calming Pills

Calm­ing Pills

A seda­tive for adults with the “speak­ing” name “Calm down” is avail­able in the form of sub­lin­gual tablets that can be con­sumed with­out drink­ing water. This inex­pen­sive home rem­e­dy is pre­scribed for increased excitabil­i­ty of the cen­tral ner­vous sys­tem, irri­tabil­i­ty, insom­nia, fre­quent migraines, as well as neu­roses asso­ci­at­ed with car­dio­vas­cu­lar dis­or­ders. Not addic­tive. It should be tak­en in the morn­ing, a quar­ter of an hour before break­fast, with­out chew­ing or swal­low­ing. Dai­ly dose — 1 tablet for 1–2 months. In stress­ful sit­u­a­tions, it is rec­om­mend­ed to take it more often, but not more than 3 times a day.

This drug should not be used to treat chil­dren under 18 years of age. It is also con­traindi­cat­ed in preg­nant and lac­tat­ing women. Patients with con­gen­i­tal lac­tase defi­cien­cy — with cau­tion.

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