Mela­tonin is a neu­ropep­tide that is respon­si­ble for cir­ca­di­an rhythms, help­ing to fall asleep and wake up (for which it was called the “sleep hor­mone”). He is also involved in the reg­u­la­tion of body tem­per­a­ture, repro­duc­tive process­es and aging process­es, slow­ing them down and increas­ing life expectan­cy, for which he also received the name “hor­mone of youth.” And the influ­ence of the hor­mone is not lim­it­ed to this: mela­tonin, its func­tions in the body are being active­ly stud­ied. There is evi­dence that this com­pound also has anti-stress and anti-can­cer effects, and its defi­cien­cy seri­ous­ly impairs well-being.

Sleep hor­mone: how is it syn­the­sized?

Sleep hormone: how is it synthesized?

Although mela­tonin has come to be called the “sleep hor­mone” because it stim­u­lates the desire to fall asleep and then wake up, it is actu­al­ly respon­si­ble for the fre­quen­cy of sleep, and is not a nat­ur­al sleep aid.

    In a healthy adult, 30 mcg of melatonin is produced daily, and at night it is almost 30 times more than during the day, and the highest amount of this hormone is synthesized at the age of three years! The peak of daily synthesis is 2 am.
    About 70% of melatonin in the body is produced in the dark, and in the light of its synthesis is sharply reduced. When the sun’s rays begin to break into the room (or a lantern is turned on at the window), its amount decreases, and awakening occurs.
    During the day, in the same pineal gland, where melatonin is actively synthesized at night, the secretion of serotonin, the “hormone of happiness and pleasure,” is activated. It is the basis for the synthesis of melatonin, serotonin itself is produced in bright light during the transformation of tryptophan. We get this amino acid from food.

If enough sero­tonin is pro­duced, then mela­tonin will be enough.

Mela­tonin is also pro­duced by the gas­troin­testi­nal tract, kid­neys and liv­er, regard­less of light­ing, but its main sup­pli­er is the pineal gland of the pineal gland.

Beyond the bio­log­i­cal clock: func­tions of mela­tonin in the body

Beyond the biological clock: functions of melatonin in the body

Some of the func­tions of mela­tonin are direct­ly relat­ed to the reg­u­la­tion of cir­ca­di­an rhythms: if you sleep “wrong­ly”, then anx­i­ety and depres­sive states devel­op, the immune and endocrine sys­tems suf­fer, and the lev­el of the hor­mone ghre­lin increas­es, which increas­es appetite.

This is not just due to lack of sleep. The same effects are observed dur­ing night work, shift­ed sched­ules of sleep and wake­ful­ness. And one of the rea­sons is mela­tonin, whose func­tions are not lim­it­ed to the reg­u­la­tion of bio­log­i­cal rhythms.

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tiramisu, dessert, cake
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    Melatonin has a pronounced antioxidant effect: it easily penetrates cell membranes and neutralizes free radicals. According to recent data, its effect is 2 times higher than that of the well-known antioxidant — vitamin E.
    Another effect of melatonin is the stabilization of the work of the psyche with anti-anxiety activity and the improvement of cognitive abilities through the stimulation of visual perception.
    In the last decade, the anticancer effect of melatonin has been actively studied: its antitumor effect has been revealed in several serious scientific papers. The hormone melatonin indirectly affects the synthesis of a compound that promotes the appearance of cancer cells. In clinical trials involving cancer patients, although not 100%, but predominantly positive effects of therapy were revealed.
    The antiamnesic effect of melatonin, which is important for the protection of neurons during ischemic brain damage, was also found.
    Melatonin is involved in the functioning of the immune system: with a deficiency, susceptibility to infections increases, since among its functions is the stimulation of immunity.

By Yraa

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